FAAP20 Antibody, FITC conjugated

Code CSB-PA750774HC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FAAP20 Polyclonal antibody
Uniprot No.
Target Names
FAAP20
Alternative Names
C1orf86 antibody; CA086_HUMAN antibody; Chromosome 1 open reading frame 86 antibody; FAAP20 antibody; Fanconi anemia associated protein of 20 kDa antibody; FP7162 antibody; RP11-181G12.3 antibody; Uncharacterized protein C1orf86 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Fanconi anemia core complex-associated protein 20 protein (14-179AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
Gene References into Functions
  1. Data suggest Rev1 protein recognition mechanism by Fanconi anemia-associated protein 20 (FAAP20). PMID: 26318859
  2. FAAP20 contains a conserved ubiquitin-binding zinc-finger domain and binds K-63-linked ubiquitin chains in vitro. The FAAP20-UBZ domain is not required for interaction with FANCA, but is required for DNA-damage-induced chromatin loading of FANCA and the functional integrity of the Fanconi anemia pathway. PMID: 22343915
  3. FAAP20-ubiquitin interaction expands beyond the compact UBZ domain and requires the folding and interaction of the otherwise disordered C-terminal tail of FAAP20 for high-affinity binding. PMID: 25414354
  4. Data indicate that RNF8 and FAAP20 (C1orf86) are needed for efficient Fanconi anemia group D2 protein FANCD2 monoubiquitination. PMID: 22705371
  5. FAAP20 is an important player involved in the Fanconi anemia pathway PMID: 22396592

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Subcellular Location
Nucleus. Chromosome.
Database Links

HGNC: 26428

OMIM: 615183

KEGG: hsa:199990

STRING: 9606.ENSP00000367808

UniGene: Hs.107101

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